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Four years ago, when Oprah managed to get down to a trim and fit 160 pounds, she thought she'd hit on a foolproof formula for permanent weight loss. Then life --in the form of a thyroid problem and a killer schedule-- intervened. Last year she was back up to the 200-pound mark and knew something had to change. After a desperately needed time-out to reflect and recharge, here's what she's learned, what she's doing differently, and what's next.

Love's first blush fading? Lost that loving feeling? Love is not all around?

If your pants feel tighter than usual, you might begin to suspect that you've gained a couple of pounds. But at what point should you begin to worry that the weight gain is serious? Could you be one of the approximately two-thirds of American adults who are either overweight or obese, with an increased risk for conditions like diabetes and heart disease? While no single measurement is perfect, here are a few ways to size yourself up.

Implementing smoke-free policies can lead to a fewer hospitalizations resulting from heart attacks, according to a new study published by the Centers for Disease Control and Prevention.

Arriving at your uncle's holiday party in suitable dress and good cheer, you are greeted at the door by an old friend from school whose name, you suddenly realize, you cannot recall.

An executive of the Chinese dairy company Sanlu Group pleaded guilty Wednesday over her role in the contaminated milk scandal that sickened nearly 300,000 infants, state-run media reported.

As many as one in eight teens in the United States may take a virginity pledge at some point, vowing to wait until they're married before having sex. But do such pledges work? Are pledge takers more likely than other teens to delay sexual activity?

Though the stigma is lessening, men are still far more likely than women to let their depression go untreated. Blame it on Rambo, Brando, or the lure of the martini, but many guys still aren't getting the help they need.

The number of cholera deaths in Zimbabwe continues to increase, a World Health Organization spokesman said Monday.

"You're going to speak with the miracle woman, right?" asks a neighbor as we search for her house, cameras in tow.

Cycling legend Lance Armstrong -- a survivor of testicular cancer -- and girlfriend Anna Hansen are expecting a baby, CNN learned Tuesday through his charitable organization.

A new tool that allows doctors to use laser surgery in complex operations has been hailed as a breakthrough in minimally invasive laser technology.

Surrogacy experts say gestational surrogacy has increased steadily since the advent of in vitro fertilization in the early 1980s, because it provides an extra layer of emotional and legal protection for the client.

Many older adults in the United States are taking a confusing combination of medications, some prescribed by doctors and others picked up over-the-counter or in health food stores.

Oooooooshie the clown knows the instant effect he has on patients.

It has been almost two years since masked men in Baghdad doused Youssif in gasoline and set him on fire. Now, he's well on the road to recovery.

It's no secret that cold and flu season peaks in winter. And if you're looking for ways to stay well, one priority, say experts, is simple: follow a wholesome diet. But during the hectic holidays, that can be a tall order.

As well as their potential for creating effective therapies for debilitating diseases, embryonic stem cells could open the door to more effective pharmaceutical drug testing, according to a leading British stem cell researcher.

Singing "Frosty the Snowman" may not seem like a big deal but for Joey Finley, who suffers from a rare condition, doctors say it's a miracle. Thanks to work with a speech language pathologist, Joey has learned to talk again.